MyBioSource.com's Anti-ENPP7 Antibody, Mouse Monoclonal is a Mouse monoclonal antibody. The Anti-ENPP7 Antibody, Mouse Monoclonal was generated using ENPP7 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunocytochemistry, and Immunofluorescence.
Description
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I membrane protein which belongs to thenucleotide pyrophosphatase/phosphodiesterase family. ENPP7/NPP-7 is expressed in the intestines and human bile. ENPP7/NPP-7 is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7/NPP-7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7/NPP-7 is also reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7/NPP-7 may be associated with human colon cancer